The research efforts of the Computational Neurophysiology Laboratory (CNL) at Yale University broadly involve functional neurosurgery, cognitive neuroscience, and monitoring in OR and NICU settings. The primary focus of our research is to improve our understanding of epilepsy and the control of seizures. In our work on epilepsy we seek to:
- Understand how seizure are generated
- Improve our methodology for sensing, analyzing and controlling aberrant brain activity
- Employ our knowledge of seizure generation, sophisticated continuous brain sensing methods, and advanced computational methods to:
- accurately locate the seizure onset area in patients with partial epilepsy
- detect and predict the onset of seizures and intervene to terminate or abort seizures once they have been detected or predicted
Our work is both highly translational and interdisciplinary. Projects in these various areas are being conducted through collaborations with investigators, in academia and industry, who are trained in, or are being trained in, multiple disciplines including neurology, neurosurgery, neurobiology, neuroscience, lab-medicine, pathology, physiology, biomedical engineering, electrical engineering, material science and mathematics.